Degrees

• B.S. Chemistry (magna cum laude) Univ. of the Philippines, Diliman. Quezon City, Philippines
• B.S. Mathematics (magna cum laude), Univ. of the Philippines, Diliman. Quezon City, Philippines
• Ph.D. Chemistry (conc. in Molecular Biology), California Institute of Technology, Pasadena, CA
• Prof. & Spec. Cert., Bioinformatics & Data Mining, University of California-San Diego, La Jolla, CA

Areas of Interest

• Computational Biology
• Structural Bioinformatics/Structural Biology
• Mathematical/Theoretical Biology
• Macromolecular X-Ray Crystallography
• Biological Data Mining

Current research projects

• Structure-Based Protein Function Prediction via Pharmacophore Modeling & Screening
• Prediction of Protein-Protein Interaction Partners
• Novel, Non-Cartesian Representation of Protein 3D Structures
• A Dual Metric for Ligand Binding Site Burial Depth in the Receptor Protein
• Prediction of Disease-Related SNPs

Publications

• Li, W., Byrnes, R.W., Hayes, J., Birnbaum, A., Reyes, V.M., Shahab, A., Mosley, C.,  Pekurovsky, D., Quinn, G.B., Shindyalov, I.N., Casanova, H., Ang, L., Berman, F., Arzberger, P.W., Miller, M., Bourne, P.E.  “The Encyclopedia of Life Project: Grid Software and Deployment.”  New Gener. Comp.  (2004)  22:127-136.
• Bourne, P., Miller, M., Baldridge, K., Baru, C., Berman, F., Byrnes, R., Casanova, H., Cotofana, N., Fountwain, T., Greenberg, J., Li, W., Mosley, C., Pekurovsky, D., Quinn, G., Reyes, V., Shin, P., Shindyalov, I., Veretnik, S.  “Encyclopedia of Life: to Open New Chapter of Biological Discovery.”  SDSC & NPACI  EnVision, (2003) Vol. 19, No. 1,  pp. 3-5
• Reyes, V.M., Greasley, S.E., Stura, E.A., Beardsley, G.P., Wilson, I.A.  “Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli.”  Acta Crystallogr D Biol Crystallogr. (2000)  Aug;56 (Pt 8):1051-4.
• Lee, H., *Reyes, V.M., Kraut, J.  “Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4.”  Biochemistry. (1996) Jun 4;35(22):7012-20. (*corresponding author)
• Reyes, V.M., Sawaya, M.R., Brown, K.A., Kraut, J.   “Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.” Biochemistry. (1995) Feb 28; 34(8):2710-23.
• Reyes, V.M., Abelson, J.N.  “In vitro synthesis of end-mature, intron-containing transfer RNAs.”   Methods Enzymol. (1989);180:63-9.
• Reyes, V.M., Abelson, J.  “Substrate recognition and splice site determination in yeast tRNA splicing.“   Cell. (1988) Nov 18;55(4):719-30.
• Reyes, V.M., Abelson, J.   “A synthetic substrate for tRNA splicing.”  Anal Biochem. 1987 Oct;166(1):90-106.
• Reyes, V.M., Newman, A., Abelson, J.   “Mutational analysis of the coordinate expression of the yeast tRNAArg-tRNAAsp gene tandem.”  Mol Cell Biol. (1986) Jul;6(7):2436-42

Links:

• Research Program
• Curriculum Vitae
• Research Group