Hans Schmitthenner

Research Scientist


Contact Information

OfficeGOS A114
Phone(585) 475-6158
Emailhfssch@rit.edu


B.S. from M.I.T. (Massachusetts Institute of Technology)

Ph.D. from Penn State (The Pennsylvania State University)

Post-Doctoral Fellow at University of Rochester

Academic and Industrial Positions

Sr. Principal Scientist at Carestream Health, Rochester NY and New Haven, CT, 2008-2010

Principal Scientist at Kodak, Rochester, NY, 1999-2008

Principal Scientist at AstraZeneca Pharmaceuticals, Rochester, 1995-1999

Assistant Professor at St. John Fisher College, Rochesterer, NY 1981-1983

Research Interests

Organic Chemistry: Synthesis of Diagnostic Molecular Imaging Agents and Peptides.
Analytical Chemistry: Chemical Instrumentation including GC-MS and HPLC-Mass Spec.
Imaging Chemistry: Synthesis of Fluorescent Dyes and MRI agents.  Purification of organic molecules, peptides, proteins, antibodies, nano-particles and nano-particle conjugates.


Selected Publications

Select Patents


Loaded Latex Optical Molecular Imaging Probes Containing Lipophilic Large Stokes Shift Dyes, Schmitthenner, Hans F*., Toa Ji, Yang, Yonghong, Harder, John W., (Carestream Health,  March 2012).


Large Stokes Shift Dye used for Optical Imaging, U.S. Patent 8,017,104 (Wang, Ruizheng; Harder, John W., Stegman, D.A., Harrison, Wm. J, Schmitthenner, Hans F. (Carestream Health, September 2011).


Organic Element for Electroluminescent Devices, US20050208326A1,WO2005093871A1, Helber, M, J., Hatwar, T. K., Schmitthenner, H. F., Bessey,P. G., Rajeswaran, M., (Eastman Kodak Company, 2005).


Solubilized Dyes for Inks, US7056375B2, Potenza, Joan. C., Madaras, Marcel, B., Schmitthenner, Hans. F., Southby. David, T., (Eastman Kodak Company, June, 2006).
Solubilized yellow dyes for inks with improved ozone and light stability, US7066992B2, Potenza, Joan, C., Madaras, Marcel,B.,Schmitthenner,Hans, F.,Southby David,T., Madaras,Mihaela,L.,(Eastman Kodak Company, June2006).


Synthesis of Peptoid Substituted Azole Compounds, US6946562B2, Diehl, Donald R., Schmitthenner, Hans F., Sonnefeld, William J., Dunlap, Richard P. (Eastman Kodak Company, 2005).


Imaging Materials Containing Peptoid Substituted Azole Couplers, US6514679B2, Diehl, Donald R., Schmitthenner, Hans F., Sonnefeld, William J., Dunlap, Richard P. (Eastman Kodak Company, 2003).


Amidine Derivatives which are Inhibitors of Nitric Oxide Synthase, US20020137750A1, Chen, Deborah, W., Empfield, James R.,  Macdonald, James E., Mattes, Kenneth C., Murray, Robert, Schmitthenner,    Hans F., (AstraZeneca, 2002).


Novel compounds (Inhibitors of Nitric Oxide Synthase), US20020137736A1, Mattes, Kenneth, Murray, Robert, Phillips, Eifion D., Schmitthenner, Hans F., (AstraZeneca,2002).
1,2,4-Triazinone Derivatives and their use in Therapy,WO9418229, Rosamond, J., Schmitthenner, Hans F*.(Fisons, 1994)


Selected Publications and Conference Proceedings

 

  • Broad Based Tissue Uptake of Polycationic Near-Infrared Polymeric Nanoparticles in Living Mice,  Orton, Sean P.; Van Praagh, Andrew D.G.; Potenza, Joan C.; Schmitthenner, Hans F.; Mclaughlin, William E.; Leevy, W. Matthew, Journal of Biomedical Nanotechnology, Volume 9, Number 1,  pp. 77-85(9) (January 2013)

Bisphosphonate targeting to specific skeletal sites in mice with whole body vibration, Rao Papineni Sean Orton, Tao Ji,Hans Schmitthenner, Wm. McLaughlin,Douglas Vizard ,Jingyi Pan, FASEB, Volume 24,(April, 2010)


"Fluorescence Quenching of Near-IR dye by Neutravidin PEGylated Gold Nanoparticles", Rao V. Papineni, Hans F. Schmitthenner, Tao Ji, Jingyi Pan, In Vivo Studies /Novel Use of Imaging Probes, WMIC , Meeting Abstracts, September 9, 2010"


"1,2,4-Triazin-6-ones As Peptidomimetic Templates for Cholecystokinin-A Agonists, H.F. Schmitthenner," K.G. Doring,E.S.Downs, and J.D.Rosamond, Peptides, Chemistry, Structure and Biology, Mayflower Sc.Ltd.,(1996)


Resolution of Heteroaryloxy-propanolamine Enantiomers by Reversed Phase HPLC of (-) Menthyl Chloroformate Derivatives, H.F. Schmitthenner, M. Fedorchuck., D. J. Walter, J. Chrom., Biomed. App., 487,197 (1989)


Synthesis of Indolizidine Alkaloids via the Intramolecular Imino Diels-Alder Reaction, Nazir A. Khatri, Hans F. Schmitthenner, Jayant Shringarpure, Steven M. Weinreb, J.Am.Chem.Soc., 103, 21, 6387 (1981)


Total Synthesis of Elaeokanine A., Hans F. Schmitthenner, Steven M. Weinreb, J. Org.Chem., 45, 3372 (1980)


Synthesis of the Ethyl Nitrone of Acetaldehyde, H. F. Schmitthenner, K.S. Bhatki, R.A. Olofson, Julian Heicklein, Organic Preparations and Procedures International, 11, 5, 249 (1979)

Select Conference Procedings


"Micro-prep HPLC and LC-MS", Waters INFORM invited speaker, Miami, FL (2007)


Prep LC and LC-MS of Imaging Materials, "Prep 2006 Symposium", Baltimore, MD (2006)


Studies in Preparative LC and Prep LC-MS, NERCDG, Rochester, NY (2002)


1,2,4-Triazin-6-ones as Peptidomimetic Choleycystokin-A Agonists, IBS's "Peptidomimetics and Small Molecule Design, Philadelphia, Pa (1995) and NERM 21, Rochester, NY (1995)