Jeffrey L. Mills

Lecturer


Contact Information

OfficeGOS A254
Phone585-475-4182
Emailjlmsch1@rit.edu

Mailing Address

Thomas H. Gosnell School of Life Sciences85 Lomb Memorial Drive, GOS A254Rochester, New York 14623


Selected Publications

  1. Kong, Q., Mills, J. L., Kundu, B., Li, X, Qing, L., Surewicz, K., Cali, I., Huang, S., Zheng, M., Swietnicki, W., Sönnichsen, F. D., Gambetti, P., Surewicz, W. K. (2013) Thermodynamic Stabilization of the Folded Domain of Prion Protein Inhibits Prion Infection in Vivo. Cell Reports. 4(2):248-254.
  2. Mills, J. L., Acton, T. B., Xiao, R., Everett, J. K., Montelione, G. T. & Szyperski, T. (2012) Solution NMR structure of the helicase associated domain BVU_0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA. Journal of Structural and Functional Genomics, 14(1):19-24.
  3. Thompson, J. M., Sgourakis, N. G., Liu, G., Rossi, P., Tang, Y., Mills, J. L., Szyperski, T., Montelione, G. T., & Baker, D. (2012) Accurate protein structure modeling using sparse NMR data and homologous structure information. Proceedings of the National Academy of Sciences of the United States of America, 109(25):9875-9880.
  4. Murphy, G. S., Mills, J. L., Miley, M. J., Machius, M., Szyperski, T., & Kuhlman, B. (2012) Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core. Structure, 20(6):1086-1096.
  5. Der, B. S., Machius, M., Miley, M. J., Mills, J. L., Szyperski, T., & Kuhlman, B. (2012) Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. Journal of the American Chemical Society, 134(1):375-385.
  6. Szyperski, T., & Mills, J. L. (2011) NMR-based structural biology of proteins in supercooled water. Journal of Structural and Functional Genomics, 12(1):1-7.
  7. Singarapu, K. K., Mills, J. L., Xiao, R., Acton, T. B., Punta, M., Fischer, M., Honig, B., Rost, B., Montelione, G. T. & Szyperski, T. (2010) Solution NMR structures of proteins VPA0419 from Vibrio parahaemolyticus and yiiS from Shigella flexneri provide structural coverage for protein domain family PFAM 04175. Proteins, 78(3):779-784.
  8. Mills, J. L., Liu, G., Skerra, A., & Szyperski, T. (2009) NMR structure and dynamics of the engineered fluorescein-binding lipocalin FluA reveal rigidification of beta-barrel and variable loops upon enthalpy-driven ligand binding. Biochemistry, 48(31):7411-7419.
  9. Shah, A. H., Cianciola, N. L., Mills, J. L. endosome maturation by mimicking GTP-Rab7. The Journal of Cell Biology, 179(5):965-980.
  10. Szyperski, T., Mills, J. L., Perl, D., & Balbach, J. (2006) Combined NMR-observation of cold denaturation in p of protein unfolding. European Biophysics Journal, 35(4):363-366.
  11. Liu, G., Mills, J. L., Hess, T. A., Kim, S., Skalicky, J. J., Sukumaran, D. K., Kupce, E., Skerra, A. & Szyperski, T. (2003) Resonance assignments for the 21 kDa engineered fluorescein-binding lipocalin FluA. Journal of Biomolecular NMR, 27(2):187-188.
  12. Aramini, J. M., Mills, J. L., Xiao, R., Acton, T. B., Wu, M. J., Szyperski, T. & Montelione, G. T. (2003) Letter to the Editor : Resonance assignments for the hypothetical protein yggU from Escherichia coli. Journal of Biomolecular NMR, 27(3):285-286.
  13. Mills, J. L., & Szyperski, T. (2002) Protein dynamics in supercooled water: the search for slow motional modes. Journal of Biomolecular NMR, 23(1):63-67.
  14. Gong, B., Zeng, H., Zhu, J., Yua, L., Han, Y., Cheng, S., Furukawa, M., Parra, R. D., Kovalevsky, A. Y., Mills, J. L., Skrzypczak-Jankun, E., Martinovic, S., Smith, R. D., Zheng, C., Szyperski, T., & Zeng, X. C. (2002) Creating nanocavities of tunable sizes: hollow helices. Proceedings of the National Academy of Sciences of the United States of America, 99(18):11583-11588.
  15. Szymczyna, B. R., Pineda-Lucena, A., Mills, J. L., Szyperski, T., & Arrowsmith, C. H. (2002) Letter to the Editor: 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR. Journal of Biomolecular NMR, 22(3):299–300.
  16. Skalicky, J. J., Mills, J. L., Sharma, S., & Szyperski, T. (2001) Aromatic ring-flipping in supercooled water: implications for NMR-based structural biology of proteins. Journal of the American Chemical Society, 123(3):388-397.
  17. Rexer, E. F., Wilbur, D. B., Mills, J. L., DeLeon, R. L., & Garvey, J. F. (2000) Production of metal oxide thin films by pulsed arc molecular beam deposition. Review of Scientific Instruments, 71(5):2125-2130.
  18. Skalicky, J. J., Sukumaran, D. K., Mills, J. L., & Szyperski, T. (2000) Toward structural biology in supercooled water. Journal of the American Chemical Society, 122(13):3230-3231.