Virology
Virus-host interactions; regulation of gene expression during viral infection.
Potential Research Project
Vesicular stomatitis virus (VSV) infection causes NF-kB activation in the host, but the mechanism of this response is unclear. Previous work suggests that the M protein of VSV is involved. To determine whether the M protein alone is responsible for NF-kB regulation, gene expression in cell extracts will be examined after transfection with wild type and mutant M genes in the absence of other viral proteins.
This material is based upon work supported by the National Science Foundation under Grant No. 0829259. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation (NSF).
