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David Borkholder

David Borkholder
Bausch and Lomb Associate Professor of Microsystems Engineering

Phone: 585-475-6067
Office: ENG/2195

Dr. David Borkholder is the Bausch and Lomb Associate Professor of Microsystems Engineering at the Rochester Institute of Technology. He holds adjunct appointments with the University of Rochester departments of Otolaryngology and Biomedical Engineering. Dr. Borkholder received the BS degree in Microelectronic Engineering from RIT, and the MS and PhD degrees in Electrical Engineering from Stanford University.  He has trained at the Marine Biological Laboratory at Woods Hole on the biology of the inner ear.

The Borkholder Laboratory works on a variety of projects in MEMs, medical devices, integrated electronics, and auditory dysfunction, with a strong focus on therapy directed microsystems and sensors. Recent research projects include implantable microsystems for intra-cochlear drug delivery (NIH NIDCD), a soldier worn blast dosimetry system (DARPA) that has been commercialized as the Blast Gauge™ and is currently used in Afghanistan for triage of potential TBI, a user guided assistive listening system (NSF), and several other physiological sensors with industrial support. Dr. Borkholder teaches courses in analog electronics, electrophysiology, biomedical sensors, and product innovation, and played a key role in the development of the biomedical engineering option within the EE department. He has published numerous articles in technical, educational, and medical literature and holds several patents related to cell-based biosensors and DNA analysis.  Dr. Borkholder is a member of the DARPA Defense Sciences Research Council (DSRC) and a chartered member of the NIH Bioengineering of Neuroscience, Vision, and Low Vision Technologies (BNVT) study section.

Prior to joining RIT, Dr. Borkholder served as the Director of Hardware Engineering at ZONARE Medical Systems, Inc. where he led electronics and ASIC development for a portable premium quality ultrasound system. At Cepheid, he served as the Director of Electronic Systems and Technical Lead, developing automated systems for DNA extraction and analysis. His doctoral thesis focused on cell based biosensors using microelectrodes for chemical warfare agent detection and pharmaceutical screening.

Dr. Borkholder is an avid scuba diver, huntsman, and malt fermentation specialist.

Current Publications

Leary Pararas EE,  Borkholder DA, Borenstein JT, "Microsystems technologies for drug delivery to the inner ear," Advanced Drug Delivery Reviews, 64(14):1650-1660 (2012).  

Johnson, D., Frisina, R., Borkholder, D.A., "In-Plane Biocompatible Microfluidic Interconnects for Implantable Microsystems," IEEE Transactions on Biomedical Engineering, 58(4):943-948 (2011).

Borkholder, D.A., Xiaoxia Zhu, Brad T. Hyatt, Alfredo S. Archilla, William J. Livingston III, and Robert D. Frisina, “Murine intracochlear drug delivery: Reducing concentration gradients within the cochlea,” Hearing Research, 268(1-2):2-11 (2010).

Borkholder, D.A., “State-of-the-art mechanisms of intracochlear drug delivery,” Current Opinions in Otolaryngology & Head and Neck Surgery, 16:472-477 (2008).

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