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Engineering, Science, & Technology

Creating, innovating, addressing challenges, solving problems, and improving the quality of lives in society.

Staphylococcus aureus is a major cause of hospital-acquired infections. The multi-drug resistant nature of certain S. aureus strains makes the discovery of new drug targets for S. aureus vital. A newly discovered virulence factor from S. aureus was described as an ortholog of NagD from... READ MORE
With advancement in technology and increased breadth of requirements of customers, organizations have to deliver innovative products in a quick and efficient way to remain competitive. While there are many theories and approaches to innovation in products, few of them are quantitative in nature.... READ MORE
Moderate resolution remote sensing data offers the potential to monitor the long and short term trends in the condition of the Earth’s resources at finer spatial scales and over longer time periods. While improved calibration (radiometric and geometric), free access (Landsat, Sentinel, CBERS), and... READ MORE
Generating motifs from known active sites and matching those motifs to an uncharacterized protein is a classic way of determining protein function. Until now, the generation of motifs has been based purely on enzymatic function. This approach does not account for situations where highly different... READ MORE
Line scanning hyperspectral imaging systems are capable of capturing accurate spatial and spectral information about a scene. These data can be useful for detecting sub-pixel targets. Such systems, however, may be limited by certain key characteristics in their design. Systems employing multiple spectrometers, or... READ MORE
PHO13 in Saccharomyces cerevisiae (budding yeast) is a para-nitrophenyl phosphatase (pNppase) of the haloacid dehalogenase (HAD) superfamily. A biological substrate for PHO13 had remained undiscovered while a knockout phenotype has only been observed in strains engineered to grow on D-xylose. The purified enzyme has... READ MORE
Elliptic curve cryptography (ECC) is an ideal choice for low-resource applications because it provides the same level of security with smaller key sizes than other existing public key encryption schemes. For low-resource applications, designing efficient functional units for elliptic curve computations over binary fields... READ MORE
Homomorphic Encryption has been considered the 'Holy Grail of Cryptography' since the discovery of secure public key cryptography in the 1970s. In 2009, a long-standing question about whether fully homomorphic encryption is theoretically plausible was affirmatively answered by Craig Gentry and his bootstrapping construction.... READ MORE
2-D Semiconductors are novel materials in the field of nano-electronics. Their unusual transport properties have led to an extensive research attention towards similar materials. Graphene has carriers that exhibit an effective "speed of light" (106 m/s) in the low energy range of This research proposes... READ MORE
In the music world, the oldest instrument is known as the singing voice that plays an important role in musical recordings. The singer's identity serves as a primary aid for people to organize, browse, and retrieve music recordings. In this thesis, we focus on... READ MORE
This thesis investigated the effect of an induction sealing process and time on the removal torque of continuous thread and child resistant plastic closures. An application torque of 19 in-lb was applied to the high density polyethylene (HDPE) bottle/closure systems. After passing the bottle/closures through... READ MORE
In the present research, 1-butyl-2,3-dimethyl-4-vinylimidazolium trifluoromethane sulfonate (triflate) was synthesized and polymerized. This is the first report of the synthesis and polymerization of this ionic liquid monomer. The resulting polymer was characterized by NMR, GPC and thermal analysis (DSC and TGA). The number average molecular... READ MORE
The objective of this thesis project is to synthesize 1,2-disubstituted cyclopropene compounds from internal alkynes and diazoacetate compounds via (2÷1] cycloaddition reactions catalyzed by rhodium acetate (Rh2(OAc)4). To date, there is no known synthetic transformation to achieve this substitution pattern. 1,2-disubstituted cyclopropene compounds are versatile... READ MORE
The goal of this study was to identify BPD markers by gene expression profiling in lung and peripheral blood mononuclear cell (PBMC) gene expression data. Studies of BPD are often focused on lung tissue, but rarely venture to find markers of the disease... READ MORE
Nucleosome positioning is critical for gene expression and of major biological interest. The high cost of experimental mapping of nucleosomal arrangements signifies the need for computational approaches to predict nucleosome positioning at high resolution. Here, we present a web-based application to fulfill this need by... READ MORE