Thomas Gaborski Headshot

Thomas Gaborski

Associate Professor
Department of Biomedical Engineering
Kate Gleason College of Engineering

585-475-4117
Office Location
Office Mailing Address
Institute Hall 73-3109

Thomas Gaborski

Associate Professor
Department of Biomedical Engineering
Kate Gleason College of Engineering

Education

BS, Cornell University; MS, Ph.D., University of Rochester

Bio

Dr. Gaborski’s laboratory focuses on the interface of nanomaterials, biology and imaging with the goal of developing novel nanomaterials that lead to improved biological research as well as the treatment of human disease. Understanding fundamental yet complex biological processes requires an ever more sophisticated set of tools. His work in ultrathin nanomembranes creates solutions to the challenges of understanding how cells and biomolecules interact in both healthy and disease states.

585-475-4117

Areas of Expertise

Currently Teaching

BIME-499
0 Credits
One semester of paid work experience in biomedical engineering.
BIME-407
3 Credits
This course is an introduction to medical devices and includes engineering and regulatory issues that are unique to these devices. Course content includes applying engineering analysis skills from prior coursework to analyze the function of medical devices. Course content also includes some historical background, an overview of existing devices and Last revised 3/25/16 2 trends, material selection, interfaces of medical devices with biological tissues, product testing, reliability, and regulations specific to the design and validation of medical devices. A substantial part of the course is a project, in which students will be required to work in teams to complete a design iteration of an existing device, including appropriate analysis and documentation.
MTSE-777
1 - 4 Credits
This course is a capstone project using research facilities available inside or outside of RIT.
BIME-770
3 Credits
Students will be introduced to both the material and cellular aspects that control and regulate cell-substrate interactions and the resulting cellular behavior including spreading, adhesion, migration and differentiation. Key material physical and surface chemistry properties will be explored as well as cellular adhesion molecules and cytoskeletal structures. In addition, cellular signaling pathways related to mechanobiology including YAP/TAZ will be discussed using current peer-review journal articles. Students will also design and propose a cell-substrate interaction study and execute feasibility experiments.
MTSE-799
1 - 4 Credits
This course is a faculty-directed tutorial of appropriate topics that are not part of the formal curriculum. The level of study is appropriate for a masters-level student.

Select Scholarship

Journal Paper
Chung, H.H., et al. "Use of Porous Membranes in Tissue Barrier and Co-culture Models." Lab on a Chip 18. (2018): 1671-1689. Print.
Chung, H.H., et al. "Extended Live-tracking and Quantitative Characterization of Wound Healing and Cell Migration with SiR-Hoechst." Experimental Cell Research 1. 2 (2018): 198-210. Print.
Carter, R.N., et al. "Ultrathin Transparent Porous Glass Membranes For Cell Culture." Biofabrication 9. 1 (2017): 1-23. Print.
Casillo, S.M., et al. "Membrane Pore Spacing Can Modulate Endothelial Cell-Substrate and Cell-Cell Interactions." ACS Biomaterials Science & Engineering 3. 3 (2017): 243-248. Print.
Ramirez, M.M. and T.R. Gaborski. "Fabrication Techniques Enabling Ultrathin Nanostructured Membranes for Separations." Electrophoresis 28. 19 (2017): 2374-2388. Print.
Chung, H.H., et al. "Porous Substrates Promote Early Endothelial Migration at the Expense of Fibronectin Fibrillogenesis." ACS Biomaterials Science & Engineering 4. 1 (2018): 222-230. Print.
Winans, Joshua, et al. "Membrane Capacity and Fouling Mechanisms for Ultrathin Nanomembranes in Dead-end Filtration." Journal of Membrane Science 499. (2016): 282-289. Print.
Winans, Joshua D., et al. "Membrane capacity and fouling mechanisms for ultrathin nanomembranes in dead-end filtration." Journal of Membrane Science 499. (2016): 282-289. Print.
Qi, Chengzhu, et al. "Influence of silicon dioxide capping layers on pore characteristics in nanocrystalline silicon membranes." Nanotechnology 26. (2015): 55706. Print.
Qi, Chengzhu, et al. "Highly Porous Silicon Membranes Fabricated from Silicon Nitride/Silicon Stacks." Small 42. 11-12 (2014): 851-855. Print.
Mazzocchi, Andrea R, et al. "Porous Membranes Promote Endothelial Differentiation of Adipose-Derived Stem Cells and Perivascular Interactions." Cellular and Molecular Bioengineering 7. 3 (2014): 369-378. Print.
DesOrmeax, Jon-Paul S, et al. "Nanoporous Silicon Nitride Membranes Fabricated from Porous Nanocrystalline Silicon Templates." Nanoscale 6. 18 (2014): 10798-10805. Print.
Nehilla, Barrett J, et al. "Endothelial Vacuolization Induced By Highly-permeable Silicon Membranes." Acta Biomateriala 10. 11 (2014): 4670-4677. Print.
Miller, Joshua J, et al. "Lift-off of Large-Scale Ultrathin Nanomembranes." Journal of Micromechanics and Microengineering 25. 1 (2014): 15011. Print.
Snyder, Jessica L, et al. "High Performance, Low Voltage Electroosmotic Pumps with Molecularly Thin Nanoporous Silicon Membranes." Proceedings of the National Academy of Sciences 110. 46 (2013): 18425-18430. Print.
Johnson, Dean G., et al. "Ultrathin Silicon Membranes for Wearable Hemodialysis." Advances in Chronic Kidney Disease 20. 6 (2013): 508-513. Print.
Gaborski, Thomas R., et al. "Dynamics of Adhesion Molecule Domains on Neutrophil Membranes: Surfing the Dynamic Cell Topography." European Biophysics Journal 42. 11-12 (2013): 851-855. Print.
Kavalenka, Maryna N, et al. "Ballistic and Non-Ballistic Gas Flow through Ultrathin Nanopores." Nanotechnology 23. 14 (2012): 145706. Print.
Invited Keynote/Presentation
Gaborski, T.R. "Engineering Porous Membranes to Optimize in Vitro Cellular Barrier Models." IEEE NANOMED. IEEE. Waikiki, HI. 4 Dec. 2018. Conference Presentation.
Gaborski, Thomas, et al. "Transparent and Ultrathin Nanomembranes for Cellular Barrier and Co-culture Models." Annual Meeting. Biomedical Engineering Society. Minneapolis, MN. 7 Oct. 2016. Conference Presentation.
Dehghani, Mehdi and Thomas Gaborski. "Feasibility of Isolating Exosomes From Biofluids Using Ultrathin Nanomembranes." International Conference on Nano Micro and Mini Channels. ASME. Washington, DC. 13 Jul. 2016. Conference Presentation.
Gaborski, Thomas R. "Ultrathin silicon-based nanomembranes can revolutionize biological separations and serve as advanced cell culture platforms." International Conference on Nanochannels, Microchannels and Minichannels. American Society for Mechanical Engineers. San Francisco, CA. 7 Jul. 2015. Conference Presentation.
Gaborski, Thomas R. "Ultrathin Membranes Promote Endothelial Differentiation of Adipose-Derived Stem Cells. Invited Presentation." World Stem Cell and Regenerative Medicine Congress. Terrapinn. London, England. 22 May 2015. Conference Presentation.
Gaborski, Thomas R. "Porous Membranes Promote Endothelial Differentiation of Adipose-Derived Stem Cells and Perivascular Interactions." Biomedical Engineering Society Annual Meeting. BMES. San Antonio, TX. 25 Oct. 2014. Conference Presentation.
Peer Reviewed/Juried Poster Presentation
Ramirez, M.M., et al. "Development of Transparent Ultrathin Membranes Capable of Modulating Cell-Substrate and Cell-Cell Interactions." Proceedings of the Materials Research Society. Ed. MRS. Phoenix, AZ: MRS.
Dehghani, M.A. and T.R. Gaborski. "Capture and Release of Extracellular Vesicles on Nanoporous Membranes." Proceedings of the ASME International Conference on Mini Micro and Nanochannels. Ed. ASME. Boston, MA: ASME.
Chung, H.H., et al. "Porous Substrates Influence Early Endothelial Migration and the Associated Fibronectin Fibrillogenesis." Proceedings of the Biomedical Engineering Society. Ed. BMES. Phoenix, AZ: BMES.
Casillo, S.M., S.J. Perry, and T.R. Gaborski. "Disrupted Surfaces of Porous Membranes Reduce YAP Nuclear Localization in Adipose-Derived Stem Cells." Proceedings of the Biomedical Engineering Society. Ed. BMES. Phoenix, AZ: BMES.
Ramirez, M.M., C. Soule, and T.R. Gaborski. "Co-Culture Membranes With Tunable Nanopore Sizes To Selectively Control Cell-Cell Communication." Proceedings of the Biomedical Engineering Society. Ed. BMES. Phoenix, AZ: BMES.
Casillo, Stephanie, et al. "Cell-Substrate and Cell-Cell Interactions in Endothelial Barrier Models on Porous Glass Membranes." Proceedings of the Annual Meeting. Ed. NA. Minneapolis, MN: Biomedical Engineering Society.