Math Modeling
Seminar
Modeling treatment of
osteoarthritis with standard therapy and senolytic
drugs
Zoom Link
here
Dr. Nourridine Siewe
Assistant Professor,
Department of Mathematics and Statistics
Rochester Institute of
Technology
Abstract:
Osteoarthritis (OA), the
most common form of joint disease, involves the progressive degradation
of articular cartilage and is a major cause of chronic disability in
aging populations. Since OA is associated with severe deficiency of
collagen type II, clinical trials considered treatment of OA by injection
with undenatured collagen type II (UC-II). Recent studies consider also
injection of senolytic drugs, like fisetin, that eliminates senescent
chondrocytes in aging patients, to reduce the negative effect of these
senescent cells on cartilage structure. In this paper we develop a
mathematical model of OA for men and, separately, for women, and use the
model to assess the efficacy of treatment by UC-II and by fisetin, alone
or in combination. Our computations show the benefits of starting
treatment early. They also show that although the effect of treatment by
fisetin on slowing the progression of OA is much smaller compared to
UC-II treatment, its effect in combination with UC-II is significantly
increased.
Intended
Audience:
Beginners, undergraduates, graduates. Those with
interest in the topic.<
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Interpreters have been requested.
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