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Golisano Institute for Sustainability operates several applied research centers capable of providing specialized solutions to businesses, governments, and organizations.

The Center for Remanufacturing and Resource Recovery conducts applied research in remanufacturing processes and technologies.

The Center for Sustainable Energy Systems conducts systems-focused applied research for waste-to-value-add, micro-grids, smart cities, smart products and remote support.

The Center for Sustainable Mobility develops viable technologies for sustainable transportation systems and interconnected smart city systems.

The Center of Excellence in Advanced & Sustainable Manufacturing is a partnership with the State of NY to help NYS manufacturers gain competitive advantages through advanced manufacturing technologies and more sustainable products and processes.

The NanoPower Research Labs conducts research on new materials and devices for power generation and storage for microelectronic components and micro-electromechanical systems.

The New York State Pollution Prevention Institute is a partnership with NYS to reduce toxic use, emissions, waste generation and natural resource consumption through applied research, technology deployment, and information dissemination.

The Printing Applications Lab (PAL) conducts research and offers training in areas of print media, including quality control, color measurement, and coating performance.