This is the first course of a two-course sequence designed to introduce biomedical engineering students to the molecular and cellular basis of life with a particular emphasis on the integration of molecular systems that underscore human physiology. This course will start with the basic chemistry of biological macromolecules and then explore the cell starting from the nucleus and moving outward. Major topics will include: DNA replication; molecular basis of inheritance; the biology of RNA; gene expression; protein synthesis; and enzyme kinetics.