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Tissue Regeneration & Mechanobiology Lab (TRAM)​

The Tissue Regeneration & Mechano-Biology Lab, headed by Prof. Wuertz-Kozak, aims to understand the cellular mechanisms underlying specific pathologies, with a focus on inflammation, and to utilize this knowledge for the development of novel treatment options that allow for tissue regeneration and pain reduction.

Specifically, the group uses cells, biomaterials, biologics, genome engineering and mechanical cues to promote tissue regeneration.

Lab News

  • December 12, 2023

    Disc4All Conference Attendees

    WuertzLab Hosts Disc4All Conference

    Professor Wuertz-Kozak hosted a successful 3-day Disc4All conference in the picturesque Finger Lakes region of New York State. 

  • January 17, 2023

    WHAM13 News Feature

    WHAM13 News Feature

    Prof. Wuertz-Kozak was interviewed by WHAM13 on the lab's work on developing new solutions for back pain. 

  • August 8, 2022

    Synfix image of spine device

    Brain and Spine Acceptance

    Our work on the incidence of reoperation and adjacent segment degeneration of anterior lumbar stand-alone fusion was accepted in Brain and Spine
    doi: 10.1016/j.bas.2022.100924

  • July 2022

    Calcium Flux

    Funding Acquisition

    Our project on a Substrate Stiffness, Topography, and TRPV4 in AF Mechanotransduction was funded by the National Institute of Health (SuRE-First R16) with $730,462.
    Support for Research Excellence (SuRE) Program (R16)


TRP channels in discogenic back pain
TRP Channels in Discogenic Back Pain

Several transient receptor potential (TRP) channels are linked to discogenic back pain, and thus represent promising therapeutic targets.

Research Project image of CRISPR/Cas9 for musculoskeletal disorders. The image from https://medium.com/
CRISPR/Cas9 for Musculoskeletal Disorders

CRISPR/Cas9 gene editing can lead to therapies that target the underlying mechanisms of age-related musculoskeletal disorders in a personalized manner.

Research Project of Electrosprayed biomaterials for drug delivery
Electrosprayed Biomaterials for Drug Delivery

Electrospraying is a gentle method to encapsulate drugs into micro- or nanoparticles for sustained release.

Research Project of Electrospun 3D skin models
Electrospun 3D Skin Models

Advanced organotypic 3D skin models, produced e.g. by electrospinning, will reduce the need for animal experimentation and will advance the capabilities for personalized medicine.

Stem cells
EVs from CRISPR-Modified Stem Cells

CRISPR-Cas9 gene editing of stem cells can be used to promote the production of extracellular vesicles (EVs) with enhanced regenerative and anti-inflammatory properties.

TLR-Associated MicroRNAs
TLR-Associated MicroRNAs

MicroRNAs are small noncoding RNAs that can modulate inflammation and catabolism in health and disease.

Our People

Headshot of Karin Wuertz-Kozak

Karin Wuertz-Kozak, Ph.D.

Kate Gleason Endowed Full Professor
Department of Biomedical Engineering
Rochester Institute of Technology

Landing image

We are looking for new colleagues and collaborators to expand our research

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