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Tissue Regeneration & Mechanobiology Lab (TRAM)​

The Tissue Regeneration & Mechano-Biology Lab, headed by Prof. Wuertz-Kozak, aims to understand the cellular mechanisms underlying specific pathologies, with a focus on inflammation, and to utilize this knowledge for the development of novel treatment options that allow for tissue regeneration and pain reduction.

Specifically, the group uses cells, biomaterials, biologics, genome engineering and mechanical cues to promote tissue regeneration.

Lab News

  • July 17, 2021


    MDPI Nanomaterials Acceptance

    MDPI Nanomaterials Acceptance

    Our work on pH-responsive Chitosan/Alginate polyelectrolyte complexes on electrospun PLGA nanofibers was published in MDPI Nanomaterials.
    doi: 10.3390/nano11071850

  • June 21, 2021


    IJCAI 2017

    Polymer Reviews Acceptance

    Our work on pH-responsive electrospun nanofibers and their applications was published in Polymer Reviews.
    doi: 10.1080/15583724.2021.1939372

  • June 02, 2021


    TRPV4

    JOR Spine Acceptance

    Our work on TRPV4 as a mediator of cell damage and inflammation induced by hyperphysiological compression was published in JOR Spine.
    doi: 10.1002/jsp2.1149

  • June 02, 2021

    extracellular vesicles

    IJMS Acceptance

    Our work on extracellular vesicles as potential mediators of psychosocial stress contribution to osteoporosis was published in the International Journal of Molecular Science.
    doi: 10.3390/ijms22115846

Research

TRP channels in discogenic back pain
TRP Channels in Discogenic Back Pain

Several transient receptor potential (TRP) channels are linked to discogenic back pain, and thus represent promising therapeutic targets.

Research Project image of CRISPR/Cas9 for musculoskeletal disorders. The image from https://medium.com/
CRISPR/Cas9 for Musculoskeletal Disorders

CRISPR/Cas9 gene editing can lead to therapies that target the underlying mechanisms of age-related musculoskeletal disorders in a personalized manner.

Research Project of Electrosprayed biomaterials for drug delivery
Electrosprayed Biomaterials for Drug Delivery

Electrospraying is a gentle method to encapsulate drugs into micro- or nanoparticles for sustained release.

Research Project of Electrospun 3D skin models
Electrospun 3D Skin Models

Advanced organotypic 3D skin models, produced e.g. by electrospinning, will reduce the need for animal experimentation and will advance the capabilities for personalized medicine.

Stem cells
EVs from CRISPR-Modified Stem Cells

CRISPR-Cas9 gene editing of stem cells can be used to promote the production of extracellular vesicles (EVs) with enhanced regenerative and anti-inflammatory properties.

TLR-Associated MicroRNAs
TLR-Associated MicroRNAs

MicroRNAs are small noncoding RNAs that can modulate inflammation and catabolism in health and disease.

Our People

Headshot of Karin Wuertz-Kozak

Karin Wuertz-Kozak, Ph.D.

Kate Gleason Endowed Full Professor
Department of Biomedical Engineering
Rochester Institute of Technology

Landing image

We are looking for new colleagues and collaborators to expand our research

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