Degenerative Disc Disease
Degenerative disc disease (DDD) is a major source of low back pain, which is not only the leading cause of activity limitation and work absence but also represents a tremendous financial burden to society. Dr. Wuertz-Kozak’s latest project, with incoming funding from NIH, aims to develop a novel, minimally-invasive approach for the treatment of DDD that relies on enhancing the regenerative and anti-inflammatory capacity of extracellular vesicles (EV) derived from mesenchymal stem cells using state-of-the-art gene editing technology. Successful completion of this study will guide future development of EV-based therapy not only for DDD, but for example also for osteoarthritis in the hands, neck, knees, and hips, which could benefit millions of people in the United States every year.
Karin Wuertz-Kozak, Principal Investigator
Additional information about Dr. Wuertz-Kozak’s research can be found at https://www.rit.edu/wuertzlab. In addition, Dr. Wuertz-Kozak is active on Twitter – follow her at @Wuertz-Lab.
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