André O. Hudson
Hudson Laboratory @ RIT
85 Lomb Memorial Dr
Rochester NY, 14623
I am a faculty member in the Thomas H. Gosnell School of Life Sciences. I received a B.S. in Biology from Virginia Union University in 2000 and a Ph.D. in Plant Biology and Pathology from Rutgers University in 2006.
My responsibilies centers around teaching and research.
1. Cell and Molecular Biology
2. Fundamentals of Plant Biochemistry and Pathology
3. Molecular Ecology
4. Biospearations: Principles and Practices
The research in my laboratory focuses on amino acid metabolism. Specifically, I am interested in aminotransferase class of enzymes. These enzymes are involved involved in the metabolism of amino acids in living organisms. The overarching theme of my research program is to elucidate the function(s) of uncharacerized enzymes involved in amino acid metabolism. In addition, I am interested in strutural biology as it relates to the three-dimensional structure of enzymes that are involved in amino acid metabolism.
Gan, HM, Gan, HY, Ahmad, NH*, Aziz, NA*, Hudson, AO, Savka, MA. (2015) Whole genome sequencing and analysis reveal insights into the genetic structure, diversity and evolutionary relatedness of luxI and luxR homologs in bacteria belonging the Sphingomonadaceae family. Front. Cell. Infect. Microbiol. 4:188. doi: 10.3389/fcimb.2014.00188.
Babbitt, GA, Alawad, MA, Schulze, KV, Hudson, AO. (2015). Synonymous codon bias and functional constraint on GC3-related DNA backbone dynamics in the prokaryotic nucleoid. Nucl. Acids Res doi:10.1093/nar/gku811.
Gan, HY, Gan, HM, Tarasco, AM*, Busairi, NI*, Barton, HA, Hudson, AO, Savka, MA. (2014). Whole genome sequences of four oligotrophic bacteria isolated from deep within a cave (>400 m): Lechuguilla Cave, New Mexico, USA. Genome Announc. 2(6):e01133-14. doi:10.1128/genomeA.01133-14.
Triassi, AJ*, Wheatley, MS*, Savka, MA, Gan, HG, Dobson, RCJ, Hudson, AO. (2014) L,L-diaminopimelate aminotransferase (DapL): A putative target for the development of narrow –spectrum antibacterial compounds. Front. Microbiol 5:509. doi: 10.3389/fmicb.2014.00509.
Gan, HY, Gan, HM, Savka, MA, Triassi, AJ*, Wheatley, MS*, Smart, LB, Fabio, ES, Hudson, AO. Whole genome sequences of thirteen endophytic bacteria isolated from shrub willow (Salix) grown in Geneva, New York. (2014) Genome Announc. 2(3):e00288-14. doi:10.1128/genomeA.00288-14.
Oliver, MR, Crowther, JM, Leeman, MM*, Kessans, SA, North, RA, Donovan KA, Griffin, MDW, Suzuki, H, Hudson, AO, Kassanmascheff, M, Dobson, RCJ. The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana (2014) Acta Cryst (F70) 663-668.
Gan, HM, Triassi, AJ*, Wheatley, MS*, Savka, MA, Hudson, AO. (2014) High quality whole genome sequences of three strains of Enterobacter sp. Isolated from Jamaican Dioscorea cayenensis (Yellow Yam). Genome Announc: 13;2(2) doi:10.1128/genomeA.00170-14.
Mckinnie, SM, Rodriquez-Lopex, EM, Vederas, JC, Crowther, JM, Suzuki, H, Dobson, RC, Leustek, T, Triassi, AJ*, Wheatley, MS*, Hudson, AO. (2014) Differential response of orthologous L,L-diaminopimelate aminotransferase (DapL) to enzyme inhibitory antibiotic lead compounds. Bioorganic and Medicinal Chemistry. 22 (1) 523-530.
Gan, HM, Hudson, AO, Rahman, A, Chan KG and Savka MA.(2013) Comparative genomic analysis of six bacteria belonging to the genus Novosphingobium: Insights into host interactions, marine adaptation and bioremediation. BMC Genomics: 14:431 doi:10.1186/1471-2164-14-431.
McGroty, SE*, Pattaniyil, DT*, Patin, D, Blanot, D, Ravichandran, AC, Suzuki, H, Dobson RCJ, Savka, MA and Hudson, AO. (2013) Biochemical Characterization of UDP-N-acetylmuramoyl-l-alanyl-d-glutamyl:meso-2,6-diaminopimelate ligase (MurE) from Verrucomicrobium spinosum DSM 4136T PLoS ONE 8(6): e66458.doi:10.1371/journal.pone.0066458.
North, R*, Kessans, S*, Atkinson, S*, Suzuki, H, Watson, A, Burgess, B, Angley, L, Hudson, AO, Varsani, A, Griffin, M, Fairbanks, A, Dobson, RCJ. (2013). Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of N-acetyl neuraminate lyase from methicillin resistant Staphylococcus aureus. Acta Cryst (F69) 306-312.
Gan, HM, McGroty, SE*, Chew, TH, Chan, KG, Buckley, LJ, Savka, MA, Hudson, AO. (2012). Whole genome sequence of Enterobacter sp. SST3, an endophyte isolated from Jamaica sugarcane (Saccharum sp) stalk tissue. Journal of Bacteriol.194: 5981-5982
Gan, HM, Chew, TH, Hudson, AO, Savka, MA. (2012). Genome sequence of Novosphingobium sp. Strain Rr02-17, a nopaline crown gall associated bacterium isolated from Vitis vinifera L. Grapevine. Journal of Bacteriol. 194: 5137-5138.
Gan, HM, Chew, TH, Hudson, AO, Savka, MA. (2012). Genome sequence of Methylobacterium sp. Strain GXF4, a xylem associated bacterium isolated from Vitis vinifera L. Grapevine. Journal of Bacteriol. 194: 5157-5158.
Nachar, VR*, Savka, FC*, McGroty, SE*, Donovan, KA*, North, RA*, Dobson, RC, Buckley, LJ, Hudson, AO (2012). Genomic and biochemical analysis of the diaminopimelate and lysine biosynthesis pathway in Verrucomicrobium spinosum: Identification and partial characterization of L,L-diaminopimelate aminotransferase and UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-meso-diaminopimelate ligase. Front. Microbio. 3:183. doi: 10.3389/fmicb.2012.00183.
Bulman,Z*, Le,P, Hudson, AO, Savka, MA (2011). A novel property of propolis (bee glue): Anti-pathogenic activity by inhibition of N-acyl-homoserine lactone mediated signaling in bacteria. Journal of Ethanopharmacology. 138. 788-797.
Dobson, RCJ, Giron, I*, Hudson, AO (2011) L,L-Diaminopimelate Aminotransferase from Chlamydomonas reinhardtii: A Target for Algaecide Development. PLoS ONE 6(5): e20439. doi:10.1371/journal.pone.0020439
Hudson, AO, Klartag, A, Gilvarg, C, Marques, FG, Leustek T (2011) Dual diaminopimelate biosynthesis pathways in Bacteroides fragilis and Clostridium thermocellum. BBA proteins and proteomics (1814):1162-1168.
Hudson, AO, Giron, I*, Dobson, R. (2011) Crystallization and preliminary X-ray diffraction analysis of l,l-diaminopimelate aminotransferase (DapL) from Chlamydomonas reinhardtii. Acta Cryst (F67) 140-143.
Hudson, AO, Ahmad, NH*, Van Buren, R*, Savka, MA. (2010) Sugarcane and Grapevine endophytic bacteria: Isolation, detection of quorum sensing signals and identification by 16 v3 rDNA sequence analysis. Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology Volume 2 ISBN (13): 978-84-614-6195-0 Pg. 801-806.
Prabhu, P*, Hudson, AO. (2010) Identification and partial characterization of an L-Tyrosine aminotransferase from Arabidopsis thaliana. Biochemistry Research International (2010) Article ID 549572.
Gan, HM*, Buckley, L, Szegedi, E, Hudson, AO, Savka, MA. (2009). Identification of an rsh gene from Novosphingobium sp. Necessary for quorum sensing signal accumulation. Journal of Bacteriology (191) 2551-2560.
Hudson, AO, Gilvarg C and Leustek T. (2008) Biochemical and phylogenetic
characterization of a novel diaminopimelate biosynthesis pathway in prokaryotes
identifies a diverged form of LL-diaminopimelate aminotransferase. Journal of
Bacteriology (190) 3256-3263.
Martin M, Saladores P*, Lambert E*, Hudson AO, Leustek T (2007). Localization of members of the γ-glutamyl transpepdidase family identifies sites of glutathione and glutathione S-conjugate hydrolysis. Plant Physiol (144) 1742-1752.
McCoy A, Adams N, Hudson AO, Gilvarg C, Leustek T, Maurelli A (2006) Chlamydia trachomatis CT390 is a transkingdom LL-diaminopimelate aminotransferase variant of the meso-diaminopimelate/lysine biosynthetic pathway. PNAS (47) 17909-17914.
Hudson, AO, Singh BK, Leustek T and Gilvarg C (2006) An L,L- diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants. Plant Physiol (140) 292-301.
Hudson, AO, Bless, C*. Macedo, P*. Chatterjee SP. Singh, BK. Gilvarg, C. Leustek, T. (2005). Biosynthesis of lysine in plants: evidence for a variant of the known bacterial pathways. Biochemica et Biophysica Acta. (1721) 27-36.
Lee, M., Martin M., Hudson AO., Lee, J., Muhitch, M., Leustek, T. (2005)
Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana. The Plant Journal. (41) 685-696.
Morgan, CA., Hudson, AO., Konopka A, Nakatsu CH. (2002) Analyses of microbial activity in biomass-recycle reactors using denaturing gradient gel electrophoresis of 16S rDNA and 16S rRNA PCR products. Can. J. Microbiol. (48) 333-341.
*Denotes Undergraduate student