News
Karin Wuertz-Kozak

Researchers in RIT's Tissue Regeneration and Mechanobiology Lab are investigating a new approach that could change how fibrosis is treated across organs in patients suffering from systemic sclerosis: targeting the protein TRPC6, a small ion channel—that can sense mechanical cues such as stiffness.

The process combines virology and mechanobiology, two distinct areas of study that had not been explored at the same time but might prove to be a way to better understand disease progressions to intervene earlier and improve patient outcomes.

Researchers are improving non-invasive treatment options for degenerative disc disease, an ailment that impacts 3 million adults yearly in the U.S. Using state-of-the-art gene editing technology in mesenchymal stem cells, the researchers will add to the growing field of regenerative medicine, the process of producing cellular therapies to alleviate pain and lack of mobility.

Karin Wuertz-Kozak described her lab test equipment as a gym for cells. Stretching and compressions tests using bioreactors—her lab equipment—can make a difference in understanding how cells respond to mechanical cues and how that affects disease progression, specifically for spinal disc degeneration, common to millions of Americans.

More collagen in the human body is not always good, and Professor Karin Wuertz-Kozak is investigating how disease progresses because of the increase in this important protein.