Vinay Abhyankar

Assistant Professor

Department of Biomedical Engineering

Kate Gleason College of Engineering

vvabme@rit.edu

585-475-4665

Office Location

INS-3105

Office Mailing Address

160 Lomb Memorial Dr Rochester, NY 14623

Vinay Abhyankar

Assistant Professor

Department of Biomedical Engineering

Kate Gleason College of Engineering

Education

BS, Binghamton University; Ph.D., University of Wisconsin

Bio

Dr. Vinay Abhyankar received his B.S. in Mechanical Engineering from Binghamton University and his M.S. and Ph.D. in Biomedical Engineering from the University of Wisconsin–Madison. After one year in technical consulting, he joined the Biotechnology and Bioengineering Department at Sandia National Laboratories in Livermore, CA. Prior to joining RIT, he led the Biological Microsystems Division at the University of Texas at Arlington Research Institute. Dr. Abhyankar’s research laboratory works at the intersection of engineering, biomaterials science, and biology.

Current work focuses on developing accessible microfluidic systems that integrate controlled microenvironments with topographically defined matrices to engineer biomimetic tissue interfaces.These technology platforms are well-suited for both undergraduate and graduate research involvement and combine simulation-based design, hands-on prototyping, and experimental studies to better understand human disease.

vvabme@rit.edu

585-475-4665

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Personal Website

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RIT students are in bold

Ahmed, A., Joshi, I. M., Goulet, M. R., Vidas, J. A., Byerley, A. M., Mansouri, M., Day, S. W., & Abhyankar, V. V. (2022). Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment. J. Vis. Exp., e64457. https://doi.org/10.3791/64457

Mansouri, M., Ahmed, A., Ahmad, S. D., McCloskey, M. C., Joshi, I. M., Gaborski, T. R., Waugh, R. E., McGrath, J. L., Day, S. W., & Abhyankar, V. V. (2022). The Modular μSiM Reconfigured: Integration of Microfluidic Capabilities to Study in vitro Barrier Tissue Models under Flow. Advanced Healthcare Materials, 2200802. https://doi.org/10.1002/adhm.202200802

McCloskey, M. C., Kasap, P., Ahmad, S. D., Su, S.-H., Chen, K., Mansouri, M., Ramesh, N., Nishihara, H., Belyaev, Y., Abhyankar, V. V, Begolo, S., Singer, B. H., Webb, K. F., Kurabayashi, K., Flax, J., Waugh, R. E., Engelhardt, B., & McGrath, J. L. (2022). The Modular µSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro. Advanced Healthcare Materials, 2200804. https://doi.org/10.1002/adhm.202200804

Hsu, M.-C., Mansouri, M., Ahamed, N. N. N., Larson, S. M., Joshi, I. M., Ahmed, A., Borkholder, D. A., & Abhyankar, V. V. (2022). A miniaturized 3D printed pressure regulator (µPR) for microfluidic cell culture applications. Scientific Reports, 12(1), 10769. https://doi.org/10.1038/s41598-022-15087-9

Ahmed, A., Mansouri, M., Joshi, I. M., Byerley, A. M., Day, S. W., Gaborski, T. R., & Abhyankar, V. V. (2022). Local extensional flows promote long-range fiber alignment in 3D collagen hydrogels. Biofabrication, 14(3), 035019. https://doi.org/10.1088/1758-5090/ac7824

Ahmed, A., Joshi, I. M., Larson, S., Mansouri, M., Gholizadeh, S., Allahyari, Z., Forouzandeh, F., Borkholder, D. A., Gaborski, T. R., & Abhyankar, V. V. (2021). Microengineered 3D Collagen Gels with Independently Tunable Fiber Anisotropy and Directionality. Advanced Materials Technologies, 6(4), 2001186. https://doi.org/10.1002/admt.202001186

Ahmed, A., Joshi, I. M., Mansouri, M., Ahamed, N. N. N., Hsu, M.-C., Gaborski, T. R., & Abhyankar, V. V. (2021). Engineering fiber anisotropy within natural collagen hydrogels. American Journal of Physiology-Cell Physiology, 320(6), C1112–C1124. https://doi.org/10.1152/ajpcell.00036.2021

Williams, M. J., Lee, N. K., Mylott, J. A., Mazzola, N., Ahmed, A., & Abhyankar, V. V. (2019). A low- cost, Rapidly Integrated Debubbler (RID) module for microfluidic cell culture applications. Micromachines, 10(6). https://doi.org/10.3390/mi10060360

Currently Teaching

BIME-411

Systems Physiology II

3 Credits

The second in a two course sequence involving the description and analysis of physiological mechanisms from a systems point of view. The focus of this course will be on the interaction between organ systems for the purpose of homeostasis. In particular, attention will be paid to feedback mechanisms that involve electrical and chemical feedback and control systems. Fluid and gas transport mechanisms associated with the cardiovascular and respiratory systems including their regulatory behavior and the function of the kidney are introduced by way of their contribution to fluid volume and pressures as well as its fundamental material exchange properties. The interaction between the systems and how they affect fluid and electrolyte balance, material exchange and disease processes will be discussed. Throughout the course, diseases and disorders of the various systems will be discussed. Students will learn to analyze the systems in a quantitative manner based on engineering analysis and how to model parts of systems.

BIME-470

Advanced Quantitative Cell Culture Techniques

3 Credits

This hands-on course gives engineering students experience with different culture platforms and analysis techniques. Students will be given experiments relating to current literature and state of the art techniques in the area of Tissue Engineering. In a project-based course style, individual experiments require multiple weeks and students will be expected to maintain their own cultures.

BIME-499

Co-op

0 Credits

One semester of paid work experience in biomedical engineering.

BIME-570

Tissue Engineering

3 Credits

BIME-670

Tissue Engineering

3 Credits

This course is intended to provide an overview of how replacement organs and tissues can be engineered using both natural and synthetic biomaterials that direct cellular differentiation and integration. The objectives of the course are to present how tissues can be engineered using the physical and chemical properties of biomaterials and targeted differentiation of multi- and pluripotent stem cells. Topics include the adhesion, migration, growth and differentiation of cells as well as the optimization and modeling of molecular and cellular transport within and across engineered tissues. Additionally, the course will investigate the engineering parameters and necessary functionality of artificial tissues. There is no laboratory component to this course. Graduate students will work in pairs to present one of the engineering fundamentals lectures listed in section 6.3 as it applies to tissue engineering. Additionally, graduate students will also be responsible for independently researching and presenting a case study on the use of stem cells in tissue engineering at the conclusion of the course.

In the News

March 22, 2023

RIT honors 14 researchers added to prestigious PI Millionaires group

RIT faculty members, who led research initiatives as principal investigators, were honored at a reception on March 21 to celebrate the individuals who helped the university reach record awards surpassing $92 million and place among the top private research universities in the country.
July 25, 2022

Vinay Abhyankar receives NSF grant to assess cancer cell migration processes

Cancer spreading from the primary tumor location to another is called metastasis and is the leading cause of cancer-related death worldwide. Research efforts today focus on discovering the guidance cues, or indicators, that promote movement of cancer cells toward blood vessels during early metastasis, and some of that work is taking place at RIT and the University of Rochester.

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