Hans Schmitthenner Headshot

Hans Schmitthenner

Research Faculty

School of Chemistry and Materials Science
College of Science

Hans Schmitthenner

Research Faculty

School of Chemistry and Materials Science
College of Science


BS, Massachusetts Institute of Technology; Ph.D., Pennsylvania State University


For more information please visit the Schmitthenner Research Group website.

Personal Links
Areas of Expertise

Select Scholarship

Peer Reviewed/Juried Poster Presentation or Conference Paper
Jones, Kelsea, et al. "Practical Modular Synthesis of Targeted Imaging Agents for MRI, PET and PET-MRI." Proceedings of the MEDI 437 256th ACS Meeting, Boston, MA 2018. Ed. ACS. Boston, MA: ACS.
Published Conference Proceedings
Schmitthenner, Hans F, et al. "Modular Synthesis of Peptide-based Single and Multimodal Targeted Molecular Imaging Agents." Proceedings of the MEDI 204., 56th ACS National Meeting, Boston, MA(2019). Ed. ACS. Boston, MA: ACS, 2018. Web.
External Scholarly Fellowships/National Review Committee
6/1/2018 - 5/31/2021
     NIH - NCI
     Amount: $ 474,279
9/1/2014 - 5/30/2018
     Amount: $ 440,000
Journal Paper
Schmitthenner, Hans F., et al. "Photoacoustic Imaging with an Acoustic Lens Detects Prostate Cancer Cells Labeled with PSMA-Targeting Near-Infrared Dye-Conjugates." Journal of Biomedical Optics 66019. 21. 6 (2016): 66019--66023. Print.
Orton, S.P., et al. "Broad Based Tissue Uptake of Polycationic Near-infrared Polymeric Nanoparticles in Living Mice." J Biomed Nanotechnol. 2013 Jan;9(1):77-85 9. 1 (2013): 77-85. Print.
Provisional Patent
Schmitthenner, Hans F., et al. "Loaded Latex Optical Molecular Imaging Probes Containing Lipophilic Large Stokes Shift Dyes." Patent US 8,906,354 B2. 12 Dec. 2014.
Schmitthenner, Hans F, et al. "Modular Imaging Agents Containing Amino Acids and Peptides." Patent 14/449,943. 1 Aug. 2014.

Currently Teaching

1 Credits
This course introduces first-year chemistry and biochemistry majors to the topics of chemical safety, ethics, database searching, citation protocol, presentation development and execution as well as the career options in the field and opportunities at RIT and beyond. These topics will be covered in the context of developing a product that the student will accomplish during the lab component of the course.
2 Credits
This course presents an introduction to working in a modern chemistry laboratory. Students will perform exercises that will aid in the understanding of general laboratory practices, atomic and molecular structure, and Lewis acid base theory. Students will also become familiar with keeping a scientific laboratory notebook and writing scientific abstracts. Students will also utilize modern chemical instrumentation to aid in the understanding of concepts.
1 - 3 Credits
This course allows students to assist in a class or laboratory for which they have previously earned credit. The student will assist the instructor in the operation of the course. Assistance by the student may include fielding questions, helping in workshops, and assisting in review sessions. In the case of labs, students may also be asked to help with supervising safety practices, waste manifestation, and instrumentation.
1 - 3 Credits
This course is a faculty-directed student project or research in chemistry that could be considered of an original nature.
1 - 3 Credits
This course is a faculty-directed student project or research involving laboratory work, computer modeling, or theoretical calculations that could be considered of an original nature. The level of study is appropriate for students in their final two years of study.
1 Credits
Chemists are required to communicate information about their research, laboratory, and themselves in writing. This course is designed to develop these skills. Students will learn how to write a curriculum vitae, resume, laboratory overview, short and long research abstracts, and scientific research articles using the various formats and styles used by chemists. An integral part of the writing of a research article is the initial formulation of the research hypothesis and design of experiments to test the hypothesis. This course will also review and stress the importance of these components.
1 - 6 Credits
Dissertation research by the candidate for an appropriate topic as arranged between the candidate and the research advisor.
0 Credits
Continuation of Thesis
3 Credits
This course will teach state of the art chemical separations and methods which are coupled to mass spectroscopy for the modern analysis of pharmaceutical and biotechnology samples in industrial and academic laboratories. These include gas chromatography (GC, GC-MS), high performance liquid chromatography (HPLC, LC-MS), solid phase extraction (SPE and SPME), size exclusion/gel permeation (SEC, GPC), and ion exchange chromatography (IXC). Aspects of mass spectroscopy including ionization methods of electron impact (EI), chemical ionization (CI), positive and negative electrospray (ES+, ES-), APCI, and MALDI and techniques involving single and multiple ion/reaction methods (SIM, SRM, MRM) will be included. The separation and analysis of peptides, proteins and pharmaceuticals by LC and LC-MS will be a major focus. Isolation of drug metabolites from serum by SPE followed by HPLC analysis or using size exclusion chromatography to separate biomolecules, or labeling a peptide with a near infrared (NIR) dye are examples of important skills that are learned.

In the News

  • December 3, 2020

    collage of four female chemistry alumni

    One Mentor, Four Success Stories (and Counting)

    It began in 2015 with a research grant, a team of undergraduates, and an outstanding mentor. Today these RIT alumni are developing new cancer therapies, celebrating a patent, writing in science journals, and teaching the next generation of scientists.

  • December 20, 2018

    logo for RIT intersections: the RIT podcast.

    Podcast: Overcoming Challenges 

    Intersections: The RIT Podcast, Ep. 5: Ricardo Carrion, a second-year chemistry major, talks with his faculty mentor, research professor Hans Schmitthenner, about overcoming life’s challenges and helping students from diverse backgrounds achieve their potential.