Hans Schmitthenner Headshot

Hans Schmitthenner

Research Faculty
School of Chemistry and Materials Science
College of Science
Research Associate Professor

585-475-6158
Office Location

Hans Schmitthenner

Research Faculty
School of Chemistry and Materials Science
College of Science
Research Associate Professor

Education

BS, Massachusetts Institute of Technology; Ph.D., Pennsylvania State University

Bio

For more information please visit the Schmitthenner Research Group website.

585-475-6158

Currently Teaching

CHMA-650
3 Credits
This course will teach state of the art chemical separations and methods which are coupled to mass spectroscopy for the modern analysis of pharmaceutical and biotechnology samples in industrial and academic laboratories. These include gas chromatography (GC, GC-MS), high performance liquid chromatography (HPLC, LC-MS), solid phase extraction (SPE and SPME), size exclusion/gel permeation (SEC, GPC), and ion exchange chromatography (IXC). Aspects of mass spectroscopy including ionization methods of electron impact (EI), chemical ionization (CI), positive and negative electrospray (ES+, ES-), APCI, and MALDI and techniques involving single and multiple ion/reaction methods (SIM, SRM, MRM) will be included. The separation and analysis of peptides, proteins and pharmaceuticals by LC and LC-MS will be a major focus. Isolation of drug metabolites from serum by SPE followed by HPLC analysis or using size exclusion chromatography to separate biomolecules, or labeling a peptide with a near infrared (NIR) dye are examples of important skills that are learned.
CHEM-790
1 - 6 Credits
Dissertation research by the candidate for an appropriate topic as arranged between the candidate and the research advisor.
CHEM-495
1 - 3 Credits
This course is a faculty-directed student project or research involving laboratory work, computer modeling, or theoretical calculations that could be considered of an original nature. The level of study is appropriate for students in their final two years of study.
CHMA-165
1 Credits
This laboratory is designed for chemistry and biochemistry majors or those interested in pursuing a minor in chemistry. Experiments include statistics, calibration of equipment, spectroscopy, volumetric analyses, kinetics, Gran Plot, double endpoint titrations, potentiometric titration, photometric determination of copper, and water hardness.
CHEM-493
1 - 3 Credits
This course is a faculty-directed student project or research in chemistry that could be considered of an original nature.
CHEM-301
1 - 3 Credits
This course allows students to assist in a class or laboratory for which they have previously earned credit. The student will assist the instructor in the operation of the course. Assistance by the student may include fielding questions, helping in workshops, and assisting in review sessions. In the case of labs, students may also be asked to help with supervising safety practices, waste manifestation, and instrumentation.
CHEM-155
2 Credits
This course presents an introduction to working in a modern chemistry laboratory. Students will perform exercises that will aid in the understanding of general laboratory practices, atomic and molecular structure, and Lewis acid base theory. Students will also become familiar with keeping a scientific laboratory notebook and writing scientific abstracts. Students will also utilize modern chemical instrumentation to aid in the understanding of concepts.
CHEM-791
0 Credits
Continuation of Thesis

Select Scholarship

Peer Reviewed/Juried Poster Presentation
Jones, Kelsea, et al. "Practical Modular Synthesis of Targeted Imaging Agents for MRI, PET and PET-MRI." Proceedings of the MEDI 437 256th ACS Meeting, Boston, MA 2018. Ed. ACS. Boston, MA: ACS.
Published Conference Proceedings
Schmitthenner, Hans F, et al. "Modular Synthesis of Peptide-based Single and Multimodal Targeted Molecular Imaging Agents." Proceedings of the MEDI 204., 56th ACS National Meeting, Boston, MA(2019). Ed. ACS. Boston, MA: ACS, 2018. Web.
External Scholarly Fellowships/National Review Committee
6/1/2018 - 5/31/2021
     NIH - NCI
     Amount: $ 474,279
9/1/2014 - 5/30/2018
     NIH-NCI
     Amount: $ 440,000
Journal Paper
Schmitthenner, Hans F., et al. "Photoacoustic Imaging with an Acoustic Lens Detects Prostate Cancer Cells Labeled with PSMA-Targeting Near-Infrared Dye-Conjugates." Journal of Biomedical Optics 66019. 21. 6 (2016): 66019--66023. Print.
Orton, S.P., et al. "Broad Based Tissue Uptake of Polycationic Near-infrared Polymeric Nanoparticles in Living Mice." J Biomed Nanotechnol. 2013 Jan;9(1):77-85 9. 1 (2013): 77-85. Print.
Provisional Patent
Schmitthenner, Hans F., et al. "Loaded Latex Optical Molecular Imaging Probes Containing Lipophilic Large Stokes Shift Dyes." Patent US 8,906,354 B2. 12 Dec. 2014.
Schmitthenner, Hans F, et al. "Modular Imaging Agents Containing Amino Acids and Peptides." Patent 14/449,943. 1 Aug. 2014.