This course provides an in-depth coverage on the application of the first and second law of thermodynamics and conservation principles, mass and energy, to the analysis of open systems and power cycles, including refrigeration, heat pump and power cycles. It also introduces the fundamentals of heat transfer theory, conduction, radiation, free and forced convection, and its application to heat exchangers including free surface and conduit flow. Case studies based on real-world thermal systems are used to illustrate the connection between these interdisciplinary subjects.