I am interested in collective behavior in soft materials, particularly biological systems that involve an interplay between mechanics, (equilibrium or non-equilibrium) statistical mechanics, geometry, and structural properties.
Rochester Institute of Technology College of Science
Soft Condensed Matter and Biological Physics
From embryogenesis, to osteoarthritis, to cancer, physical forces and mechanical properties of tissues play a key role in health and disease. Many physical models of tissues largely focus on a single level of complexity e.g. individual cells or large collections of cells. A multi-scale approach is critically needed to address the complex interplay of mechanisms at each level, and bridge the gap between models at different levels. My long-term goal is to use multi-scale modeling to explain how mechanical forces are sensed and transmitted from molecules to cells to tissues, and how these processes impact tissue dynamics, properties, and biological functions. To this end, my group uses a combination of analytical theory and computer simulations to investigate time-dependent mechanical properties of tissues based on interplay of mechanics, geometry, and statistical physics of underlying components. Our models are informed and tested via close collaborations with experimental labs.
Active and Passive Transport of Cargo in a Corrugated Channel, S. Dey, K. Ching, and M. Das, J. Chem. Phys. 148, 134907 (2018).
Triggered disassembly and reassembly of actin networks induces rigidity phase transitions, B. Gurmessa, N. Bitten, J. L. Ross, D. T. Nguyen, O. A. Saleh, M. Das, and R. M. Robertson-Anderson, arXiv:1710.03781, to appear in Soft Matter.
Chase and run dynamics and molecular rupture of interacting elastic dimers, D. Mayett, N. Bitten, M. Das, and J. M. Schwarz, Phys. Rev. E 96, 032407 (2017)
Dynamic self-organization of microwell-aggregated cellular mixtures, W. Song, C.K. Tung Y.C. Lu, Y. Pardo, M. Wu, M. Das, D. Kao, S. Chen, and M. Ma, Soft Matter 12, 5739(2016)
Mechanics of anisotropic spring networks, T. Zhang, J.M. Schwarz, and M. Das, Phys. Rev. E 90, 062139 (2014).
Structure-function relations and rigidity percolation in the shear properties of neonatal bovine articular cartilage, J.L. Silverberg, A.R. Barrett, M. Das, P.B. Peterson, L. Bonassar, and I. Cohen, Biophys J 107, 1721 (2014), Selected to feature in Cover Page of Issue.
Active elastic dimers: Cells moving on featureless tracks, J. Lopez, M. Das, and J. M. Schwarz, Phys. Rev. E 90, 032707 (2014), Selected as a Editor’s Suggestion.
Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks, M. Das, D. Quint and J.M. Schwarz, PLoS ONE 7, 35939 (2012).
Mechanics of soft composites of rods in elastic gels, M. Das and F.C. MacKintosh, Phys. Rev. E 84, 061906 (2011).
Poisson’s ratio and microrheology of composite elastic materials with rigid rods, M. Das and F.C. MacKintosh, Phys. Rev. Lett. 105, 138102 (2010).
Buckling and force propagation along intracellular microtubules, M. Das, Alex J. Levine, and F.C. MacKintosh, Europhys. Lett. 84, 18003 (2008).
Effective medium theory of semiflexible filamentous networks, M. Das, F.C. Mack- intosh and A.J. Levine, Phys. Rev. Lett. 99, 038101 (2007).
Curvature condensation and bifurcation in an elastic shell, M. Das, A. Vaziri, A. Kudrolli and Mahadevan, Phys. Rev. Lett. 98, 014301 (2007).
Persistence of a pinch in an elastic pipe, L. Mahadevan, A. Vaziri and M. Das, Euro- physics Lett. 77, 40003 (2007).
Brownian-drag induced particle current in a model colloidal system, M. Das, S. Ramaswamy, A.K. Sood and G. Ananthakrishna, Phys. Rev. E 73, 061409 (2006).
Routes to spatiotemporal chaos in the rheology of nematogenic fluids, M. Das, B. Chakrabarti, C. Dasgupta, S. Ramaswamy, and A. K. Sood, Phys. Rev. E 71, 021707 (2005).
Rheological Chaos in Wormlike Micelles and nematic hydrodynamics, M. Das, R. Bandyopadhyay, B. Chakrabarti, S. Ramaswamy, C. Dasgupta, and A. K. Sood, in Molecular Gels, ed. P. Terech, and R. G. Weiss (Springer, 2006).
Spatiotemporal rheochaos in nematic hydrodynamics, B. Chakrabarti, M. Das, C. Dasgupta, S. Ramaswamy and A. K. Sood, Phys. Rev. Lett. 92, 055501 (2004).
Collective stochastic resonance in shear-induced melting of sliding bilayers, M. Das, G. Ananthakrishna, and S. Ramaswamy, Phys. Rev. E 68, 0161402 (2003).
Melting-freezing cycles in a relatively sheared pair of crystalline monolayers, M. Das, S. Ramaswamy, and G. Ananthakrishna, Europhys. Lett. 60, 636 (2002).
External: Research Corporation for Science Advancement. Gordon and Betty Moore Foundation. National Science Foundation (CBET & DMR). Keck Foundation.
Internal: Dean's Research Initiation Grant, College of Science, RIT.