Chemistry Seminar: All Things Carbene
All Things Carbene: The Non-Precious Metal Catalyzed Conversion of Readily Available Starting Materials into Complex Molecular Building Blocks and Imaging Agents
Dr. Michael Coleman
Professor of Organic Chemistry
School of Chemistry and Materials Science, RIT
The talk will be an overview of newly developed methods towards the synthesis of novel imaging science agents and other biologically-relevant materials utilizing carbene compounds and transition metal catalysts will be presented.
Abstract:
Carbenes are reactive intermediates whose electronic interactions with transition metal atoms have the capacity to span the full spectrum of electrophilic and nucleophilic reactive states in addition to serving as ancillary ligands for tunable organometallic catalyzed transformations. Ongoing efforts in my research laboratory have sought to leverage their versatility as reagents for the straightforward, atom economical, non-precious metal catalyzed conversion of unsaturated compounds into highly chemo , regio-, and stereoselective carbocylic and heterocyclic products. An overview of newly developed methods towards the synthesis of novel imaging science agents and other biologically-relevant materials utilizing carbene compounds and transition metal catalysts will be presented.
Speaker Bio:
Michael G. Coleman, Ph.D. is a native of Rochester, New York. He received his B.S. in Chemistry from the University at Buffalo in 1998. After serving four years as a research chemist developing transition-metal organic complexes for the selective adsorption of O2 gas from atmospheric air at the Research and Development division of Praxair, Inc, he returned to the University at Buffalo Department of Chemistry to join Professor Huw M.L. Davies’ group. In 2007, he received his Ph.D. in Synthetic Medicinal Chemistry, and shortly thereafter he occupied a summer NSF Visiting REU Scholar position at the University of Cincinnati where he developed iron-catalyzed Oppenauer-like oxidations of alcohols and regioselective cycloaddition reactions. He later held two summer appointments at Brookhaven National Laboratory in the laboratory of Dr. Joanna Fowler studying organometallic radiochemical transformations for the positron emission tomography of 11C- and 18F-radiolabeled plant hormones. In 2008, he joined the faculty at RIT as a Visiting Professor and was later promoted to Associate Professor in 2015. His research interests include the development of novel synthetic organometallic methodologies towards complex and biologically relevant targets using readily available starting materials.
Intended Audience:
Undergraduates, graduates, and experts. Those with interest in the topic.
Event Snapshot
When and Where
Who
Open to the Public
Interpreter Requested?
No