Chemistry Seminar: Monitoring lysine acetylationvia novel carbon-detect nuclear magnetic resonance (NMR) methods
Chemistry Seminar
Monitoring lysine acetylationvia novel carbon-detect nuclear magnetic resonance (NMR) methods
Olivia Fraser ’20
Biochemistry, Microbiology, and Molecular Biology Ph.D. Candidate
Penn State University
RIT Chemistry MS Alumna ’20
Register Here for Zoom Link
This seminar is hosted by the RIT Student Chapter of the American Society of Biochemistry and Molecular Biology (ASBMB)
Abstract:
Post translational modifications (PTMs), such as lysine acetylation, alter protein functions in response to changing cellular conditions. Proteins involved in gene regulation, such as disordered histone tails, can undergo lysine acetylation in a manner associated with euchromatin formation and gene upregulation. Although this system is well-studied, more molecular level detail is necessary to understand the mechanism by which acetylation affects the function of nonhistone proteins. Current methods for monitoring lysine acetylation require improvement, as they provide information only on bulk acetylation state or preclude the study of downstream macromolecular interactions. I will describe a novel NMR method which will be advantageous due to the possibility for site-specific resolution and the ability to detect structural changes.
Speaker Bio:
Olivia graduated from RIT in 2020 with an MS in chemistry and was jointly advised by Dr. Lea Michel and Dr. George Thurston. She is now a second year Ph.D. student in the Biochemistry, Microbiology, and Molecular Biology program at Penn State University in Scott Showalter’s lab. The Showalter Lab studies intrinsically disordered proteins in the context of eukaryotic gene regulation using biophysical methods. Olivia is a Center of Eukaryotic Gene Regulation (CEGR) trainee and the secretary of the Huck Graduate Student Advisory Committee. During her Ph.D., she hopes to develop NMR methods which can help to uncover the mechanisms by which PTMs function in a combinatorial method to control gene regulation.
Intended Audience:
Undergraduates, graduates, experts. Those with interest in the topic.
To request an interpreter, please visit myaccess.rit.edu
Event Snapshot
When and Where
Who
Open to the Public
Interpreter Requested?
No