Chemistry Seminar: Solvent-Free High-Speed Ball Milling
Solvent-Free High-Speed Ball Milling: The Mechanochemical Carbene Transfer Reactions
Mahima Donga
Chemistry MS Candidate
School of Chemistry and Materials Science, RIT
Ms. Donga will discuss using solvent - free High - speed Ball - milling (HSBM) as a powerful mechanochemical technique for the solvent-free synthesis of complex compounds.
Abstract:
Solvents contribute to at least more than 50% of the chemical waste. Many industries use large quantities of flammable, volatile solvents for chemical manufacturing and services. Often, many of these solvents are toxic and are released into the environment by passive routes or improper disposal. One way to reduce the usage of toxic solvents is to incorporate the concept of green chemistry when developing and executing a chemical process. Mechanochemistry is an ancient method for the synthesis of chemicals by using force/pressure. Recently, mechanochemical approaches have been derived from Green chemistry which are very efficient and sustainable solutions. Solvent - free High - speed Ball - milling (HSBM) is a powerful mechanochemical technique for the solvent-free synthesis of complex compounds. Our research project aims to measure the efficiency and selectivity of mechanochemical organic synthetic transformations. Carbene transfer reactions are an interesting class of reactions to explore due to the possibility for interesting and unexpected product(s). Also, traditional carbene transfer reactions are conducted in high volumes of solvent over a slow addition time (typically > 12 hrs). This extra technical step is due to the propensity of these highly reactive carbene intermediates to undergo a dimerization reaction when they collide with each other. This reaction is often considered an unwanted side-reaction. The solvent-free high-speed ball milling (HSBM) reduces and eliminates the by-product dimerization pathways by imparting enough kinetic force necessary to generate the carbenes over an infinitesimally short period of time without the need for slow-addition reaction. The homogeneous catalyzed cyclopropanation of styrene and diazoacetates was a highly efficient (up to 95% isolated yield) and highly chemo- and diastereoselective (up to 95%) rapidly in (~1 hr) under ambient conditions.
Speaker Bio:
Mahima received her BS in Chemistry from University of Mumbai (India). She came to RIT in Fall 2019 to pursue her master’s in Chemistry. Her research interests include synthesis of organic compounds and green chemistry. In her free time she likes to paint, sketch or play badminton.
Intended Audience:
All are welcome.
To request an interpreter, please visit myaccess.rit.edu@rit.edu
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