Math Modeling Seminar: A QSP PDE Model of ADC Transport and Kinetics in a Growing or Shrinking Tumor
Math Modeling Seminar
A QSP PDE Model of ADC Transport and Kinetics in a Growing or Shrinking Tumor
Zoom Link here
Dr. David Ross
Director of QSP
GSK Consumer Healthcare
Abstract:
An oncological antibody-drug conjugate (ADC) is a medicine that combines the receptor-targeting property of a monoclonal antibody with the cell-killing property of a cytotoxic small molecule. When a tumor is treated with an ADC, complex biochemistry occurs in a domain–the tumor–whose size and structure are changing. Some parts of the tumor may be growing because tumor cells proliferate. Other parts may be stagnant, or nearly so, because the cells there have been damaged by the cytotoxin. Still others may be shrinking because the cells there have been killed by the cytotoxin and are being cleared. Chemical concentrations within the tumor, which influence kinetics and transport, change as the tumor grows or shrinks. Cell surface antigen, to which ADCs are designed to bind, is lost when cells are cleared and is freshly introduced when cells proliferate. For these reasons, and because shrinking the tumor by killing its cells is the purpose of ADC treatment, it is important in a quantitative systems pharmacology (QSP) approach to the problem to model the evolution of tumor size and structure over the course of ADC treatment. In this talk Dr. Ross will present a partial differential equation model of ADC transport and kinetics in a growing and shrinking tumor.
Speaker Bio:
David Ross took his PhD in math from NYU, where he wrote a dissertation on aerodynamic shock waves. He spent many years at Kodak Research Labs before joining the SMS faculty at RIT. He retired from RIT several years ago, and these days he is doing applied math at GSK. His primary mathematical interests are PDE and dynamical systems.
Intended Audience:
Beginners, undergraduates, graduates. Those with interest in the topic.
Interpreters have been requested.
Event Snapshot
When and Where
Who
This is an RIT Only Event
Interpreter Requested?
Yes