Math Modeling Seminar - Quantitative Imaging of the Liver and Other Organs

Quantitative Imaging of the Liver and Other Organs

Professor Sir Michael Brady
Professor of Oncological Imaging
Department of Oncology
University of Oxford

Zoom Registration Link

Abstract:
There is a World-wide pandemic in liver and metabolic diseases, driven in the West by obesity and in Asia (primarily) by the prevalence of hepatitis B. MRI potentially offers a way to assess organs such as the liver, kidneys, and pancreas; however, MRI is currently qualitative, in the sense that the brightness values in a typical scan have little or no intrinsic meaning. Hence, the interpretation of an MRI relies upon clinician judgement; but, the inter- and intra-rater variation is typically 35%. In a University of Oxford start-up, Perspectum https://perspectum.com/, we have used mathematical modelling to determine the amount of fat at each voxel of the liver and the amount of iron, and we measure the degree of fibroinflammation. The resulting FDA-cleared product LiverMultiscan is the basis for many pharmaceutical trials (from the San Francisco office) and for a clinical service (from the Dallas office). Further, we have developed methods to extract and measure the biliary tree in a liver cancer resection decision support tool, Hepatica. More recently, we have extended LiverMultiscan to a product, Atlas, that can assess organ damage following COVID-19.

Speaker Bio:
Professor Sir Michael Brady is currently Professor in Oncological Imaging in the Department of Oncology at the University of Oxford, having recently retired as Professorship in Information Engineering (1985-2010). Prior to Oxford, he was Senior Research Scientist in the Artificial Intelligence Laboratory at MIT, where he was one of the founders of the Robotics Laboratory. Mike is the author of over 400 articles and 35 patents in computer vision, robotics, medical image analysis, and artificial intelligence, and the author or editor of ten books, including: Robot Motion (MIT Press 1984), Robotics Science (MIT Press 1989), Robotics Research (MIT Press 1984), Mammographic Image Analysis (Kluwer, January 1999) and Images and Artefacts of the Ancient World (British Academy, 2005) and the International Workshop on Digital Mammography (Springer 2006). He was Editor of the Artificial Intelligence Journal (1987-2002), and founding Editor of the International Journal of Robotics Research (1981-2000). Mike is co-Director of the Oxford Cancer Imaging Centre, one of four national cancer imaging centres in the UK.
Mike has been elected a Fellow of the Royal Society, Fellow of the Royal Academy of Engineering, Membre Associé Etranger of the Académie des Sciences, Honorary Fellow of the Institution of Engineering and Technology, Fellow of the Institute of Physics, Fellow of the Academy of Medical Sciences, and Fellow of the British Computer Society. He was awarded the IEE Faraday Medal for 2000, the IEEE Third Millennium Medal for the UK, the Henry Dale Prize (for “outstanding work on a biological topic by means of an original multidisciplinary approach”) by the Royal Institution in 2005, and the Whittle Medal by the Royal Academy of Engineering 2010. Mike was knighted in the New Year’s honours list for 2003. He has been awarded honorary doctorates by the universities of Essex, Manchester, Liverpool, Southampton, Oxford Brookes, York, and Paul Sabatier (Toulouse, France), and has been appointed an Honorary Professor at the Chongqing University of Posts and Telecommunications and Chongsha's South China University. He was named Alumnus of the Year in 2019 by the Australian National University and awarded an honorary doctorate in 2020. Mike was Chairman of the publications board of the Royal Society 2010-2016.
Mike has a continuing strong commitment to commercialisation of science, in particular to entrepreneurial activity. He was a non-executive director and Deputy Chairman 1994-September 2014 of the FTSE 250 company Oxford Instruments plc (http://www.oxinst.com/), and from 1994-2004 a non-executive director of AEA Technology plc.  He resigned from the latter position because one of his companies, Mirada Solutions Ltd, was acquired in 2003 by CTI Molecular Imaging, a NASDAQ quoted company, and he was invited to serve on the board of CTI Mirada. Mike is a founding Director of the start-up companies: Volpara Healthcare Technologies (http://volparasolutions.com/) mammographic image analysis; Perspectum Diagnostics liver image analysis by MRI (http://perspectum-diagnostics.com/ ); and Mirada Medical Limited (http://www.mirada-medical.com/) which develops medical image analysis software (installed in almost 6000 hospitals worldwide). He was also Founder Chairman of Guidance (http://www.guidance.eu.com/) which sold its Monitoring Division (offender tagging) to G4S in 2011, its Industrial Division in 2016, and the remaining Marine Division in 2017. Most recently he has co-founded ScreenPoint bv (http://www.screenpoint-medical.com/), which provides decision support for breast cancer (2D/3D mammography, MRI) and Optellum (http://www.optellum.com/), which analyses lung CT images.

Intended Audience:
Undergraduates, graduates, and experts. Those with interest in the topic.

The Math Modeling Seminar will recur each week throughout the semester on the same day and time. Find out more about upcoming speakers on the Mathematical Modeling Seminar Series webpage.