Studying the effects of the mechanical, geometrical, and morphological environment on tumor growth
Presented by Speaker: Kristen Mills, Associate Professor of Mechanical Engineering, RPI
Solid tumor development is influenced at every stage by its biomechanical environment. The biomechanical environment of a solid tumor, characterized by abnormally stiff tissue and increased mechanical stresses, presents different tissue-level biomechanical signals than those received during healthy tissue development. In healthy tissue growth and morphogenesis cell shape and mechanical tension are important for determining cell division orientation. In tumor growth, these growth and morphogenic processes are deregulated as evidenced by aberrant growth patterns and a loss of order. It is not known what aspects of the growth process affect tumor cell shape and tumor cell response to the mechanical environment. Using primarily experimental models, we are addressing questions of tumor cell – matrix interactions from the cellular to the multi-cellular scale.
When and Where
Open to the Public