Chemistry Seminar: A Novel Plant Hormone Imaging Agent
Studies Towards the Synthesis and Biological Activity of 2-Halo-1- AminoCyclopropane Carboxylic Acid: A Novel Plant Hormone Imaging Agent
Yi Zheng
Chemistry MS Candidate
School of Chemistry and Materials Science, RIT
Mr. Zheng will discuss research into the synthesis of [18F]-ACC as a novel plant hormonal positron emission topography [PET] imaging agent.
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Abstract:
Plant hormones are a collective term for a series of signaling molecules that regulate plant growth. The simplest structure of plant hormones is ethylene. Ethylene is involved in regulating many plant physiological activities, including germination, results, and so on. At the same time, ethylene is also an important signaling molecule for plant stress. 1- Aminocyclopropane-1-carboxylic acid or ACC is an important precursor for the biosynthesis of ethylene in plants. It also plays an important role in the transportation of ethylene by plants. We are currently using classic organic chemistry methodologies from readily available materials to synthesize 2- halo-ACC analogues that will be investigated for phenotypic responses in the plant model Arabidopsis thaliana. The long-term goal of this work is to develop a practical route for the radiochemical synthesis of [18F]-ACC as a novel plant hormonal positron emission topography [PET] imaging agent. Furthermore, its subsequent metabolism to [18F]-ethylene by ACC oxidase is an interesting proposition and has the potential to become a new radioanalytical method for rapid radiometabolomics and modeling in plants. Our hypothesis is that [18F]-ACC and [18F]-ethylene will be important plant imaging agent to understand how resource allocation for plant growth and development is affected by environmental stress.
Speaker Bio:
Yi Zheng received his BS in chemistry in Zhengzhou University in China. He wanted to experience a completely different learning and cultural environment, so he came to RIT. His research interest is biochemistry.
Intended Audience:
Undergraduates, graduates, experts. Those with interest in the topic.
To request an interpreter, please visit myaccess.rit.edu
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